Reliable DNA extraction lays the groundwork for high-quality sequencing, ensuring accuracy and consistency across all downstream analyses.

Vazyme’s ready-to-use extraction reagents deliver exceptional sample compatibility and consistent purity across diverse sources — including fresh or frozen nuclear-free anticoagulated peripheral blood, bone marrow, umbilical cord blood, concentrated blood, dried blood spots (DBS), and swab samples.

Paired with Vazyme Automatic Nucleic Acids Extraction Instruments (VNP-32P and VNP-96P), the system supports both 32-sample and 96-sample formats, flexibly meeting varying throughput needs. With a compact, space-efficient design and high operational efficiency, it ensures stable and reproducible DNA purification, delivering high yields and superior purity for downstream sequencing applications.

• DM102 multiple compatibility test

Concentration and Purity

Figure 1. gDNA Yield of Other Samples

DM102 consistently delivers higher DNA yield than Supplier A, Supplier B, and Supplier C, regardless of sample type. For laboratories seeking stable and reproducible output, this advantage translates into stronger downstream performance and fewer repeat extractions.

Figure 2. gDNA Purity of Other Samples

For DBS and swab samples, DM102 achieves purity levels comparable to Supplier A and Supplier B. It is important to note that when DNA concentrations are below 50 ng/μl, lower OD260/230 values do not indicate poor purity; this is expected and should not be used as a reference indicator.
For other sample types, DM102 matches the performance of Supplier B and outperforms Supplier A, offering cleaner extracts suitable for sensitive applications.

Different anticoagulated blood samples

Figure 3. Agarose Gel Electrophoresis Images of gDNA from Different Anticoagulated Blood Samples

Fresh swab samples naturally contain high RNA levels, and minor residual RNA may appear across all tested kits — easily removable with RNase A.
For other sample types, no residual RNA is detected with DM102.
Overall, DM102 demonstrates significantly lower residual protein compared with Supplier A and Supplier B, providing higher-quality nucleic acid extracts that support robust and reliable sequencing workflows.

Other samples

Figure 4. Agarose Gel Electrophoresis Images of gDNA from Other Samples

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A fast, flexible, and platform-ready library preparation workflow is essential for delivering high-quality sequencing results with maximum efficiency.

• Broad DNA Compatibility

Vazyme’s library preparation kit is engineered to perform reliably across diverse DNA inputs — from FFPE and cfDNA to blood and swab gDNA. This broad compatibility ensures stable library quality regardless of sample origin, supporting both routine and challenging exome applications.

• Flexible Fragmentation Options

To adapt to different laboratory setups and experimental goals, the workflow offers both mechanical and enzymatic fragmentation routes. This flexibility allows users to choose the method that best matches their preferred workflow, desired fragment profiles, or available instrumentation.

• Platform-Ready Design 

All reagents and adapters are validated for Illumina and MGI sequencing systems, enabling smooth integration and predictable sequencing performance across mainstream NGS platforms. The platform versatility also allows laboratories to standardize library prep across different sequencing instruments.

• High Efficiency and Automation Compatibility

The optimized workflow produces high-quality libraries in as little as three hours, accelerating turnaround time without sacrificing consistency.

For high-throughput environments, plate-based reagents designed for automated workstations reduce hands-on time by approximately 1.5 hours per run, strengthening reproducibility and simplifying day-to-day operations.

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Precise target enrichment is key to achieving reliable sequencing depth and uniformity, ensuring that every variant is confidently detected.

Vazyme’s hybridization capture solution consistently delivers high on-target rates and uniform target coverage across both manual and automated workflows, guaranteeing dependable and reproducible performance. Its scalable design allows researchers to transition seamlessly from small-batch experiments to high-throughput sequencing projects without compromising data quality.
The system supports both magnetic bead-based and vacuum concentration methods, providing laboratories with operational flexibility to meet different throughput needs and workflow preferences.

(1) Vazyme Hybridization Capture vs. Other Suppliers
A higher on-target rate and superior target coverage distinguish Vazyme’s hybridization capture products from other suppliers.

(2) Performance of WES – Manual vs. Automated Operation

Vazyme’s WES solution demonstrates consistently high performance across both manual and automated workflows, with no significant difference in on-target efficiency or coverage uniformity.

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From sequencing to interpretation, integrated data analysis transforms raw reads into actionable genetic insights with accuracy, speed, and complete data security.

Vazyme’s Whole Exome Sequencing workflow is fully compatible with major sequencing platforms, including MGI, Illumina, and Element, providing laboratories with the flexibility to integrate seamlessly into existing sequencing ecosystems.

The streamlined Germline Variant Analysis System automates key bioinformatics processes — from quality control and sequence alignment to variant calling and functional annotation. It supports both raw sequencing data and VCF file input, and automatically initiates analysis once sequencing is completed, enabling efficient, end-to-end exome data processing. The system accurately detects SNPs, indels, and CNVs, and applies advanced annotation and filtering algorithms to prioritize variants with potential pathogenic relevance.

Key Analysis Features

a. Platform Compatibility — Supports variant classification and reporting from any NGS platform.
b. Robust Annotation — Incorporates curated commercial databases such as HGMD, with regular updates to ensure accuracy.
c. Fast & Reliable — Streamlines variant classification through standardized guidelines, reducing manual workload and turnaround time.
d. Clinical-Grade Classification — Provides ACMG-based variant interpretation, particularly optimized for exome-level analysis.
e. Customizable Reports — Integrates lab-specific reporting policies, enabling reusable internal annotations and consistent output formatting.

Analysis Workflow